A new research at the University of Bonn shows that a ketogenic diet may help to prevent bronchial asthma attacks. Using a mouse model, the researchers connected a ketogenic weight loss plan to a huge reduction of inflammation inside the respiratory tract.
Patients who suffer from bronchial asthma can relate to an intense inflammatory reaction from even low exposure to certain allergens. This inflammation is escorted by a rise in mucus production, which makes breathing even more difficult.
The cells of the innate immune system, called Innate Lymphoid Cells (ILCs), play a central function in allergies flare-ups. ILCs protect the lungs by way of regenerating broken mucous membranes. To do this, the cells produce inflammatory messengers that boost the mucosal cells and raise mucus production.
The ILC system enables the body repair damage induced by dangerous substances, that are removed from the bronchial tubes thru mucus. “With asthma, however, the inflammatory response is much more potent and longer than normal,” defined Dr. Christoph Wilhelm.
The current study suggests that if the ILC multiplication technique is slowed down, dangerous asthma attacks can be avoided.
“We have investigated which metabolic processes are active inside the ILCs when they transfer to reproduction mode,” defined Dr. Fotios Karagiannis. “Then we tried to block these metabolic pathways and thereby reduce the rate at which the cells disengage.”
Some metabolic pathways are substantially majorly active in dividing ILCs. For example, extra fatty acids are furnished to help the cells make their membranes. Dr. Karagiannis explained that activated ILCs soak up fatty acids from their surroundings and store them in their interior for a brief time, before using them for energy or building membranes.
The researchers desired to recognize what would be the result if the cells were pressured to use these fatty acids elsewhere. To investigate, they put mice on a ketogenic weight loss plan consisting of primarily fats and very few carbohydrates or proteins.
The ketogenic diet plan is understood to change cellular metabolism, and cells shift to fat burning for energy. This means that cells will lack the fatty acids that facilitate ILC reproduction.
Among the mice fed a ketogenic diet, the division pastime of ILCs was determined to be substantially decreased. “Normally, contact with allergens increases the number of ILCs within the bronchi fourfold,” said Dr. Wilhelm. “In our experimental animals, however, it remained nearly unchanged. Both mucus manufacturing and different asthma signs and symptoms reduced accordingly.”
Among the mice fed a ketogenic diet, the division activity of ILCs was determined to be substantially decreased. “Normally, contact with allergens increases the number of ILCs within the bronchi fourfold,” said Dr. Wilhelm. “In our experimental animals, however, it remained nearly unchanged. Both mucus manufacturing and different asthma signs and symptoms reduced accordingly.”
The ketogenic food plan also leads to glucose deficiency, which probably contributed to the weakened ILC activity.
“The occurrence of bronchial asthma has elevated dramatically over the last few decades. Perhaps that is also related to an increasingly common high-sugar and high-fat diet,” said Dr. Wilhelm.
Going forward, the professionals will direct their attention on patients to research whether or not a ketogenic food plan can prevent asthma attacks. “We are trying to determine which components of the dietary change are chargeable for the effect,” stated Dr. Wilhelm. “Maybe this may open the door to the development of latest drugs.”
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